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KMID : 0359320010410030401
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Korean Journal of Veterinary Research
2001 Volume.41 No. 3 p.401 ~ p.406
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Studies on genetic monitoring of inbred mice in conventional breeding unit
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이흥식/Lee, Heung Shik
김철규/Kim, Chul Kyu
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Abstract
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These studies were carried out to survey the genetic contamination of six inbred mice(!,Balb/c, C3H, C57Bl/6, CBA and KK) produced and supplied from the conventional breeding unit for improving the quality of mice as experimental animal. We examined alleles of five loci (AKp-1, Car-2, Hbb, Es-1 and Trf) by the use of biochemical markers with celluose acetate electrophoresis. As the results of test, BALB/c, A, C3H, C57BL/6, CBA and KK showed standard alleles in Akp-1, Car-2 and Hbb. But Es-1 of A and C57Bl/6 and Trf of A, C3h, C57BL/6 and CBA did allelic divergence in loci. These results suggest that the colonies of A, C3H, C57BL/6 and CBA were genetically contaminated. Therefore, we recommend to eliminate the genetically contaminated mice thoroughly, to check on genetic monitoring regularly and to consider a counterpaln for improving the quality control as soon as possibel.
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